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doi: 10.3389/fnut.2025.1679494 Received 04 August 2025 Revised 19 October 2025 Accepted 25 December 2025 Published 22 January 2026 Volume 12 - 2025 Edited by Manuela Machado, Escola Superior de Biotecnologia - Universidade Catlica Portuguesa, Portugal Reviewed by Ivan oa, University of Rijeka, Croatia Moumita Saha, Yale University, United States Updates Copyright 2026 Chang, Lin, Renn, Liu, Yen, Liao, Tikhonova, Amstislavskaya, Singh and Chen

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Several small studies have investigated the clinical efficacy and safety of onabotulinumtoninA, which have shown that it can be a safe and effective option in this population, especially in individuals who are unable to tolerate medications or are not candidates for neurosurgery